Revenue Recognition - Disaggregation of Revenue (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Disaggregation of Revenue [Line Items]
Product revenues, net	$ 2,493.2	$ 2,196.2	$ 4,868.0	$ 4,293.7
United States
Disaggregation of Revenue [Line Items]
Product revenues, net	1,507.8	1,415.1	2,911.6	2,783.3
Europe
Disaggregation of Revenue [Line Items]
Product revenues, net	800.0	655.5	1,607.2	1,287.8
Other
Disaggregation of Revenue [Line Items]
Product revenues, net	185.4	125.6	349.2	222.6
Total product revenues outside of the United States
Disaggregation of Revenue [Line Items]
Product revenues, net	985.4	781.1	1,956.4	1,510.4
TRIKAFTA/KAFTRIO
Disaggregation of Revenue [Line Items]
Product revenues, net	2,240.4	1,893.2	4,337.1	3,654.8
KALYDECO
Disaggregation of Revenue [Line Items]
Product revenues, net	125.3	138.7	250.3	277.7
ORKAMBI
Disaggregation of Revenue [Line Items]
Product revenues, net	96.3	121.6	218.8	253.7
SYMDEKO/SYMKEVI
Disaggregation of Revenue [Line Items]
Product revenues, net	$ 31.2	$ 42.7	$ 61.8	$ 107.5