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Insider Trading Arrangements
 3 Months Ended 6 Months Ended
Jun. 30, 2023
shares
Jun. 30, 2023
shares
Trading Arrangements, by Individual    
Material Terms of Trading Arrangement   The following table describes the written plans for the sale of our securities adopted by our executive officers and directors during the second quarter of 2023, each of which is intended to satisfy the affirmative defense conditions of Rule 10b5-1 (each, a “Trading Plan”).
Name and TitleDate of Adoption of Trading PlanScheduled Expiration Date of Trading Plan (1)Maximum Shares Subject to Trading Plan
David Altshuler
EVP, Global Research and Chief Scientific Officer
5/10/20235/17/2024
32,896(2)
Carmen Bozic
EVP, Global Medicines Development and Medical Affairs, Chief Medical Officer
5/30/20231/31/2024
33,905
Amit Sachdev
EVP, Chief Patient Officer
5/9/20235/20/2024
40,128(2)
Ourania Tatsis
EVP, Chief Regulatory and Quality Officer
5/9/20235/1/2024
11,783(2)
Sangeeta Bhatia
Director
5/10/20235/10/2024
1,194
Terrence Kearney
Director
5/9/202312/29/2023
10,000
(1) A Trading Plan may expire on an earlier date if all contemplated transactions are completed before such Trading Plan’s expiration date, upon termination by broker or the holder of the Trading Plan, or as otherwise provided in the Trading Plan.
(2) Does not include shares of common stock that may be withheld for taxes at future vesting dates.
Non-Rule 10b5-1 Arrangement Adopted false  
Rule 10b5-1 Arrangement Terminated false  
Non-Rule 10b5-1 Arrangement Terminated false  
David Altshuler [Member]    
Trading Arrangements, by Individual    
Name David Altshuler  
Title EVP, Global Research and Chief Scientific Officer  
Rule 10b5-1 Arrangement Adopted true  
Adoption Date 5/10/2023  
Arrangement Duration 373 days  
Aggregate Available 32,896 32,896
Carmen Bozic [Member]    
Trading Arrangements, by Individual    
Name Carmen Bozic  
Title EVP, Global Medicines Development and Medical Affairs, Chief Medical Officer  
Rule 10b5-1 Arrangement Adopted true  
Adoption Date 5/30/2023  
Arrangement Duration 246 days  
Aggregate Available 33,905 33,905
Amit Sachdev [Member]    
Trading Arrangements, by Individual    
Name Amit Sachdev  
Title EVP, Chief Patient Officer  
Rule 10b5-1 Arrangement Adopted true  
Adoption Date 5/9/2023  
Arrangement Duration 377 days  
Aggregate Available 40,128 40,128
Ourania Tatsis [Member]    
Trading Arrangements, by Individual    
Name Ourania Tatsis  
Title EVP, Chief Regulatory and Quality Officer  
Rule 10b5-1 Arrangement Adopted true  
Adoption Date 5/9/2023  
Arrangement Duration 358 days  
Aggregate Available 11,783 11,783
Sangeeta Bhatia [Member]    
Trading Arrangements, by Individual    
Name Sangeeta Bhatia  
Title Director  
Rule 10b5-1 Arrangement Adopted true  
Adoption Date 5/10/2023  
Arrangement Duration 366 days  
Aggregate Available 1,194 1,194
Terrence Kearney [Member]    
Trading Arrangements, by Individual    
Name Terrence Kearney  
Title Director  
Rule 10b5-1 Arrangement Adopted true  
Adoption Date 5/9/2023  
Arrangement Duration 234 days  
Aggregate Available 10,000 10,000