Revenue Recognition - Disaggregation of Revenue (Details) - USD ($) $ in Millions	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Disaggregation of Revenue [Line Items]
Product revenues, net	$ 2,374.8	$ 2,097.5
United States
Disaggregation of Revenue [Line Items]
Product revenues, net	1,403.8	1,368.2
Europe
Disaggregation of Revenue [Line Items]
Product revenues, net	807.2	632.3
Other
Disaggregation of Revenue [Line Items]
Product revenues, net	163.8	97.0
Total product revenues outside of the United States
Disaggregation of Revenue [Line Items]
Product revenues, net	971.0	729.3
TRIKAFTA/KAFTRIO
Disaggregation of Revenue [Line Items]
Product revenues, net	2,096.7	1,761.6
KALYDECO
Disaggregation of Revenue [Line Items]
Product revenues, net	125.0	139.0
ORKAMBI
Disaggregation of Revenue [Line Items]
Product revenues, net	122.5	132.1
SYMDEKO/SYMKEVI
Disaggregation of Revenue [Line Items]
Product revenues, net	$ 30.6	$ 64.8