Hedging - Cash Flow Hedging Instruments (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Derivative Instruments, Gain (Loss) [Line Items]
Product revenues, net	$ 8,930.7	$ 7,574.4	$ 6,205.7
Other (expense) income, net	(164.8)	4.9	296.6
Foreign Currency Forward Contract | Reclassification out of Accumulated Other Comprehensive Income | Foreign currency forward contracts | Not designated as hedging instrument
Derivative Instruments, Gain (Loss) [Line Items]
Other (expense) income, net	(9.9)	(18.6)	22.1
Product revenues, net
Derivative Instruments, Gain (Loss) [Line Items]
Product revenues, net	8,930.7	7,573.4	6,202.8
Product revenues, net | Foreign Currency Forward Contract | Reclassification out of Accumulated Other Comprehensive Income | Foreign currency forward contracts | Designated as hedging instruments
Derivative Instruments, Gain (Loss) [Line Items]
Product revenues, net	$ 182.5	$ (30.0)	$ (3.7)