Additional Balance Sheet Detail (Tables)

12 Months Ended

Dec. 31, 2022

Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract]

Schedule of Prepaid, and Other Assets

“Prepaid expenses and other current assets” consisted of the following:

	As of December 31,
	2022		2021
	(in millions)
Tax related prepaid and receivables	$	319.8	$	358.6
Prepaid expenses	111.8		83.5
Fair value of cash flow hedges	47.5		44.5
Other	74.4		59.2
Total	$	553.5	$	545.8

Summary of Accrued Expenses

“Accrued expenses” consisted of the following:

	As of December 31,
	2022		2021
	(in millions)
Product revenue accruals	$	1,300.8	$	847.4
Payroll and benefits	246.5		191.3
Research, development and commercial contract costs	198.7		171.6
Royalty payable	215.0		200.4
Tax related accruals	123.3		211.3
Other	42.4		56.6
Total	$	2,126.7	$	1,678.6

Summary of Other Current Liabilities

“Other current liabilities” consisted of the following:

	As of December 31,
	2022		2021
	(in millions)
Contract liabilities	$	159.6	$	171.7
Finance lease liabilities	40.8		46.9
Operating lease liabilities	48.6		33.3
Other	62.5		16.5
Total	$	311.5	$	268.4

Summary of Other Long Term Liabilities

“Other long-term liabilities” consisted of the following:

	As of December 31,
	2022		2021
	(in millions)
Tax related liabilities	$	452.8	$	—
Contingent consideration	114.4		186.5
Other	118.6		116.8
Total	$	685.8	$	303.3

Schedule of Additional Cash Flow Information

The cash, cash equivalents and restricted cash balances at the beginning and ending of each period presented in our consolidated statements of cash flows consisted of the following:

	As of December 31,
	2022		2021		2020		2019
	(in millions)
Cash and cash equivalents	$	10,504.0	$	6,795.0	$	5,988.2	$	3,109.3
Prepaid expenses and other current assets	8.0		5.1		0.7		8.0
Other assets	—		—		—		3.4
Cash, cash equivalents and restricted cash per consolidated statements of cash flows	$	10,512.0	$	6,800.1	$	5,988.9	$	3,120.7