Acquired In-Process Research and Development and Other Arrangements (Tables)

12 Months Ended

Dec. 31, 2022

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Schedule of Collaborative Arrangement Costs

During the three years ended December 31, 2022, we recognized the following amounts in total, not including amounts recorded to “Acquired in-process research and development expenses,” related to these agreements:

	2022		2021		2020
	(in millions)
Total expenses incurred under the Original CTX001 JDCA and A&R JDCA	$	365.8	$	230.4	$	101.2
Vertex’s share recognized in “Total costs and expenses” in our consolidated statements of operations	251.1		129.0		50.6