Consolidated Statements of Operations - USD ($) shares in Millions, $ in Millions	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Revenues:
Revenue	$ 8,930.7	$ 7,574.4	$ 6,205.7
Costs and expenses:
Cost of sales	1,080.3	904.2	736.3
Research and development expenses	2,540.3	1,937.8	1,644.9
Acquired in-process research and development expenses	115.5	1,113.3	184.6
Selling, general and administrative expenses	944.7	840.1	770.5
Change in fair value of contingent consideration	(57.5)	(3.1)	13.1
Total costs and expenses	4,623.3	4,792.3	3,349.4
Income from operations	4,307.4	2,782.1	2,856.3
Interest income	144.6	4.9	22.2
Interest expense	(54.8)	(61.5)	(58.2)
Other (expense) income, net	(164.8)	4.9	296.6
Income before provision for income taxes	4,232.4	2,730.4	3,116.9
Provision for income taxes	910.4	388.3	405.2
Net income	$ 3,322.0	$ 2,342.1	$ 2,711.7
Net income per common share:
Basic (in dollars per share)	$ 12.97	$ 9.09	$ 10.44
Diluted (in dollars per share)	$ 12.82	$ 9.01	$ 10.29
Shares used in per share calculations:
Basic (in shares)	256.1	257.7	259.8
Diluted (in shares)	259.1	259.9	263.4
Product revenues, net
Revenues:
Revenue	$ 8,930.7	$ 7,573.4	$ 6,202.8
Other revenues
Revenues:
Revenue	$ 0.0	$ 1.0	$ 2.9