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Segment Information
 12 Months Ended
Dec. 31, 2022
Segment Reporting [Abstract]  
Segment Information Segment Information
Segment reporting is prepared on the same basis that our chief executive officer, who is our chief operating decision maker, manages the business, makes operating decisions and assesses performance. We operate in one segment, pharmaceuticals. Enterprise-wide disclosures about revenues, significant customers, and property and equipment, net by location are presented below.
Revenues by Product
Product revenues, net consisted of the following:
202220212020
(in millions)
TRIKAFTA/KAFTRIO$7,686.8 $5,697.2 $3,863.8 
SYMDEKO/SYMKEVI180.0 420.4 628.6 
ORKAMBI510.7 771.6 907.5 
KALYDECO553.2 684.2 802.9 
Total product revenues, net$8,930.7 $7,573.4 $6,202.8 
Product Revenues by Geographic Location
Net product revenues are attributed to countries based on the location of the customer and consisted of the following:
202220212020
(in millions)
United States$5,699.3 $5,287.3 $4,826.4 
Outside of the United States
Europe2,705.5 1,972.9 1,126.5 
Other
525.9 313.2 249.9 
Total product revenues outside of the United States
3,231.4 2,286.1 1,376.4 
Total product revenues, net
$8,930.7 $7,573.4 $6,202.8 
Significant Customers
Gross product revenues and accounts receivable from each of our customers who individually accounted for 10% or more of total gross product revenues and/or 10% or more of total accounts receivable consisted of the following:
Percent of
Total Gross Product Revenues
Percent of
Accounts Receivable
Year Ended December 31,
As of December 31,
20222021202020222021
McKesson Corporation25 %22 %20 %22 %21 %
Accredo Health Group, Inc.12 %12 %15 %<10%10 %
Walgreen Co.10 %10 %14 %<10%<10 %
Lloyds Pharmacy*<10%<10%<10%12 %15 %
*A wholly-owned subsidiary of McKesson Corporation in the U.K. until 2022.
Long-lived Assets by Location
Long-lived assets by location consisted of the following:
As of December 31,
20222021
(in millions)
United States$1,365.5 $1,348.1 
Outside of the United States
United Kingdom75.7 60.9 
Other14.6 15.4 
Total long-lived assets outside of the United States90.3 76.3 
Total long-lived assets$1,455.8 $1,424.4