Stock-based Compensation Expense and Share Repurchase Programs - Stock-based Compensation Expense (Details) - USD ($) $ in Millions	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Stock-based compensation expense:
Total stock-based compensation expense included in “Total costs and expenses”	$ 135.6	$ 103.0	$ 379.8	$ 322.8
Stock-based compensation expense related to inventories	0.3	(0.7)	0.4	(3.8)
Total stock-based compensation expense included in “Total costs and expenses”	135.6	103.0	379.8	322.8
Income tax effect	(38.8)	(21.6)	(101.3)	(73.7)
Total stock-based compensation expense, net of tax	96.8	81.4	278.5	249.1
Cost of sales
Stock-based compensation expense:
Total stock-based compensation expense included in “Total costs and expenses”	2.4	1.6	7.0	4.6
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation expense included in “Total costs and expenses”	80.0	61.0	229.9	196.4
Selling, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation expense included in “Total costs and expenses”	53.2	40.4	142.9	121.8
Restricted stock units (including PSUs)
Stock-based compensation expense:
Total stock-based compensation expense included in “Total costs and expenses”	130.3	89.5	351.5	279.1
Stock options
Stock-based compensation expense:
Total stock-based compensation expense included in “Total costs and expenses”	3.1	7.9	14.9	29.6
ESPP share issuances
Stock-based compensation expense:
Total stock-based compensation expense included in “Total costs and expenses”	$ 1.9	$ 6.3	$ 13.0	$ 17.9