Revenue Recognition - Disaggregation of Revenue (Details) - USD ($) $ in Millions	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Disaggregation of Revenue [Line Items]
Revenues	$ 2,334.3	$ 1,984.1	$ 6,628.0	$ 5,501.8
United States
Disaggregation of Revenue [Line Items]
Revenues	1,455.6	1,382.9	4,238.9	3,893.2
Europe
Disaggregation of Revenue [Line Items]
Revenues	730.5	518.8	2,018.3	1,382.7
Other
Disaggregation of Revenue [Line Items]
Revenues	148.2	82.4	370.8	224.9
Total product revenues outside of the United States
Disaggregation of Revenue [Line Items]
Revenues	878.7	601.2	2,389.1	1,607.6
Product revenues, net
Disaggregation of Revenue [Line Items]
Revenues	2,334.3	1,984.1	6,628.0	5,500.8
TRIKAFTA/KAFTRIO
Disaggregation of Revenue [Line Items]
Revenues	2,010.5	1,555.8	5,665.3	4,004.6
SYMDEKO/SYMKEVI
Disaggregation of Revenue [Line Items]
Revenues	38.2	81.4	145.7	340.0
ORKAMBI
Disaggregation of Revenue [Line Items]
Revenues	146.2	184.5	399.9	624.2
KALYDECO
Disaggregation of Revenue [Line Items]
Revenues	$ 139.4	$ 162.4	$ 417.1	$ 532.0