Revenue Recognition (Tables)

9 Months Ended

Sep. 30, 2022

Revenue from Contract with Customer [Abstract]

Schedule of Disaggregation of Revenue

Product revenues, net consisted of the following:

	Three Months Ended September 30,				Nine Months Ended September 30,
	2022		2021		2022		2021
	(in millions)
TRIKAFTA/KAFTRIO	$	2,010.5	$	1,555.8	$	5,665.3	$	4,004.6
SYMDEKO/SYMKEVI	38.2		81.4		145.7		340.0
ORKAMBI	146.2		184.5		399.9		624.2
KALYDECO	139.4		162.4		417.1		532.0
Total product revenues, net	$	2,334.3	$	1,984.1	$	6,628.0	$	5,500.8

Total net product revenues by geographic region, based on the location of the customer, consisted of the following:

	Three Months Ended September 30,				Nine Months Ended September 30,
	2022		2021		2022		2021
	(in millions)
United States	$	1,455.6	$	1,382.9	$	4,238.9	$	3,893.2
Outside of the United States
Europe	730.5		518.8		2,018.3		1,382.7
Other	148.2		82.4		370.8		224.9
Total product revenues outside of the United States	878.7		601.2		2,389.1		1,607.6
Total product revenues, net	$	2,334.3	$	1,984.1	$	6,628.0	$	5,500.8