Condensed Consolidated Statements of Operations - USD ($) shares in Millions, $ in Millions	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Revenues:
Revenues	$ 2,334.3	$ 1,984.1	$ 6,628.0	$ 5,501.8
Costs and expenses:
Cost of sales	289.4	236.5	797.0	656.8
Research and development expenses	645.0	467.0	1,846.2	1,370.0
Acquired in-process research and development expenses	29.0	26.7	92.9	986.8
Selling, general and administrative expenses	246.8	198.2	677.3	584.9
Change in fair value of contingent consideration	(2.6)	1.2	(59.3)	(1.1)
Total costs and expenses	1,207.6	929.6	3,354.1	3,597.4
Income from operations	1,126.7	1,054.5	3,273.9	1,904.4
Interest income	46.2	1.1	58.6	3.7
Interest expense	(13.7)	(15.2)	(43.2)	(46.4)
Other income (expense), net	17.2	42.4	(133.7)	(2.2)
Income before provision for income taxes	1,176.4	1,082.8	3,155.6	1,859.5
Provision for income taxes	245.9	230.9	652.5	287.5
Net income	$ 930.5	$ 851.9	$ 2,503.1	$ 1,572.0
Net income per common share:
Basic (in dollars per share)	$ 3.63	$ 3.30	$ 9.78	$ 6.08
Diluted (in dollars per share)	$ 3.59	$ 3.28	$ 9.68	$ 6.03
Shares used in per share calculations:
Basic (in shares)	256.5	257.9	255.8	258.7
Diluted (in shares)	259.5	259.7	258.7	260.9
Product revenues, net
Revenues:
Revenues	$ 2,334.3	$ 1,984.1	$ 6,628.0	$ 5,500.8
Other revenues
Revenues:
Revenues	$ 0.0	$ 0.0	$ 0.0	$ 1.0