Hedging - Cash Flow Hedging Instruments (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Derivative Instruments, Gain (Loss) [Line Items]
Product revenues, net	$ 2,196.2	$ 1,793.4	$ 4,293.7	$ 3,517.7
Other (expense) income, net	(78.1)	8.1	(150.9)	(44.6)
Foreign Currency Forward Contract | Reclassification out of Accumulated Other Comprehensive Income | Foreign Currency Forward Contracts | Not designated as hedging instruments
Derivative Instruments, Gain (Loss) [Line Items]
Other (expense) income, net	(8.4)	(1.0)	(16.8)	(9.0)
Product revenues, net
Derivative Instruments, Gain (Loss) [Line Items]
Product revenues, net	2,196.2	1,793.4	4,293.7	3,516.7
Product revenues, net | Foreign Currency Forward Contract | Reclassification out of Accumulated Other Comprehensive Income | Foreign Currency Forward Contracts | Designated as hedging instruments
Derivative Instruments, Gain (Loss) [Line Items]
Product revenues, net	$ 45.0	$ (17.6)	$ 65.1	$ (34.1)