Revenue Recognition - Disaggregation of Revenue (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Disaggregation of Revenue [Line Items]
Product revenues, net	$ 2,196.2	$ 1,793.4	$ 4,293.7	$ 3,517.7
United States
Disaggregation of Revenue [Line Items]
Product revenues, net	1,415.1	1,256.9	2,783.3	2,510.4
Europe
Disaggregation of Revenue [Line Items]
Product revenues, net	655.5	458.9	1,287.8	863.9
Other
Disaggregation of Revenue [Line Items]
Product revenues, net	125.6	77.6	222.6	142.4
Total product revenues outside of the United States
Disaggregation of Revenue [Line Items]
Product revenues, net	781.1	536.5	1,510.4	1,006.3
Product revenues, net
Disaggregation of Revenue [Line Items]
Product revenues, net	2,196.2	1,793.4	4,293.7	3,516.7
TRIKAFTA/KAFTRIO
Disaggregation of Revenue [Line Items]
Product revenues, net	1,893.2	1,255.6	3,654.8	2,448.8
SYMDEKO/SYMKEVI
Disaggregation of Revenue [Line Items]
Product revenues, net	42.7	133.5	107.5	258.6
ORKAMBI
Disaggregation of Revenue [Line Items]
Product revenues, net	121.6	221.0	253.7	439.7
KALYDECO
Disaggregation of Revenue [Line Items]
Product revenues, net	$ 138.7	$ 183.3	$ 277.7	$ 369.6