Revenue Recognition (Tables)

6 Months Ended

Jun. 30, 2022

Revenue from Contract with Customer [Abstract]

Schedule of Disaggregation of Revenue

Product revenues, net consisted of the following:

	Three Months Ended June 30,				Six Months Ended June 30,
	2022		2021		2022		2021
	(in millions)
TRIKAFTA/KAFTRIO	$	1,893.2	$	1,255.6	$	3,654.8	$	2,448.8
SYMDEKO/SYMKEVI	42.7		133.5		107.5		258.6
ORKAMBI	121.6		221.0		253.7		439.7
KALYDECO	138.7		183.3		277.7		369.6
Total product revenues, net	$	2,196.2	$	1,793.4	$	4,293.7	$	3,516.7

Total net product revenues by geographic region, based on the location of the customer, consisted of the following:

	Three Months Ended June 30,				Six Months Ended June 30,
	2022		2021		2022		2021
	(in millions)
United States	$	1,415.1	$	1,256.9	$	2,783.3	$	2,510.4
Outside of the United States
Europe	655.5		458.9		1,287.8		863.9
Other	125.6		77.6		222.6		142.4
Total product revenues outside of the United States	781.1		536.5		1,510.4		1,006.3
Total product revenues, net	$	2,196.2	$	1,793.4	$	4,293.7	$	3,516.7