Segment Information - Revenue by Geographic Location (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenues from External Customers and Long-Lived Assets [Line Items]
Total product revenues, net	$ 7,574.4	$ 6,205.7	$ 4,162.8
Product revenues, net
Revenues from External Customers and Long-Lived Assets [Line Items]
Total product revenues, net	7,573.4	6,202.8	4,160.7
United States | Product revenues, net
Revenues from External Customers and Long-Lived Assets [Line Items]
Total product revenues, net	5,287.3	4,826.4	3,060.3
Europe | Product revenues, net
Revenues from External Customers and Long-Lived Assets [Line Items]
Total product revenues, net	1,972.9	1,126.5	885.9
Other | Product revenues, net
Revenues from External Customers and Long-Lived Assets [Line Items]
Total product revenues, net	313.2	249.9	214.5
Total product revenues outside of the United States | Product revenues, net
Revenues from External Customers and Long-Lived Assets [Line Items]
Total product revenues, net	$ 2,286.1	$ 1,376.4	$ 1,100.4