Segment Information - Revenues by Product (Details) $ in Millions	12 Months Ended
	Dec. 31, 2021 USD ($) segment	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)
Revenue from External Customer [Line Items]
Number of operating segments | segment	1
Total product revenues, net	$ 7,574.4	$ 6,205.7	$ 4,162.8
TRIKAFTA/KAFTRIO
Revenue from External Customer [Line Items]
Total product revenues, net	5,697.2	3,863.8	420.1
SYMDEKO/SYMKEVI
Revenue from External Customer [Line Items]
Total product revenues, net	420.4	628.6	1,417.7
ORKAMBI
Revenue from External Customer [Line Items]
Total product revenues, net	771.6	907.5	1,331.9
KALYDECO
Revenue from External Customer [Line Items]
Total product revenues, net	684.2	802.9	991.0
Product revenues, net
Revenue from External Customer [Line Items]
Total product revenues, net	$ 7,573.4	$ 6,202.8	$ 4,160.7