Hedging - Cash Flow Hedging Instruments (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Derivative Instruments, Gain (Loss) [Line Items]
Product revenues, net	$ 7,574.4	$ 6,205.7	$ 4,162.8
Other income, net	4.9	296.6	192.2
Foreign Currency Forward Contract | Reclassification out of Accumulated Other Comprehensive Income | Foreign currency forward contracts | Not designated as hedging instrument
Derivative Instruments, Gain (Loss) [Line Items]
Other income, net	(18.6)	22.1	(4.8)
Product revenues, net
Derivative Instruments, Gain (Loss) [Line Items]
Product revenues, net	7,573.4	6,202.8	4,160.7
Product revenues, net | Foreign Currency Forward Contract | Reclassification out of Accumulated Other Comprehensive Income | Foreign currency forward contracts | Designated as hedging instruments
Derivative Instruments, Gain (Loss) [Line Items]
Product revenues, net	$ (30.0)	$ (3.7)	$ 32.5