Consolidated Balance Sheets - USD ($) $ in Millions	Dec. 31, 2021	Dec. 31, 2020
Current assets:
Cash and cash equivalents	$ 6,795.0	$ 5,988.2
Marketable securities	729.9	670.7
Accounts receivable, net	1,136.8	885.4
Inventories	353.1	280.8
Prepaid expenses and other current assets	545.8	308.3
Total current assets	9,560.6	8,133.4
Property and equipment, net	1,094.1	958.5
Goodwill	1,002.2	1,002.2
Intangible assets	400.0	400.0
Deferred tax assets	934.5	882.8
Operating lease assets	330.3	325.6
Other assets	110.8	49.3
Total assets	13,432.5	11,751.8
Current liabilities:
Accounts payable	195.0	155.1
Accrued expenses	1,678.6	1,405.0
Other current liabilities	268.4	317.4
Total current liabilities	2,142.0	1,877.5
Long-term finance lease liabilities	509.8	539.0
Long-term operating lease liabilities	377.4	350.5
Long-term contingent consideration	186.5	189.6
Other long-term liabilities	116.8	108.4
Total liabilities	3,332.5	3,065.0
Commitments and contingencies	0.0	0.0
Shareholders’ equity:
Preferred stock, $0.01 par value; 1,000,000 shares authorized; none issued and outstanding	0.0	0.0
Common stock, $0.01 par value; 500,000,000 shares authorized, 254,479,046 and 259,889,549 shares issued and outstanding, respectively	2.5	2.6
Additional paid-in capital	6,880.8	7,894.0
Accumulated other comprehensive income (loss)	15.9	(68.5)
Retained earnings	3,200.8	858.7
Total shareholders’ equity	10,100.0	8,686.8
Total liabilities and shareholders’ equity	$ 13,432.5	$ 11,751.8