Consolidated Statements of Operations - USD ($) shares in Millions, $ in Millions	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenues:
Revenue	$ 7,574.4	$ 6,205.7	$ 4,162.8
Costs and expenses:
Cost of sales	904.2	736.3	547.8
Research and development expenses	3,051.1	1,829.5	1,754.5
Selling, general and administrative expenses	840.1	770.5	658.5
Change in fair value of contingent consideration	(3.1)	13.1	4.5
Total costs and expenses	4,792.3	3,349.4	2,965.3
Income from operations	2,782.1	2,856.3	1,197.5
Interest income	4.9	22.2	63.7
Interest expense	(61.5)	(58.2)	(58.5)
Other income, net	4.9	296.6	192.2
Income before provision for income taxes	2,730.4	3,116.9	1,394.9
Provision for income taxes	388.3	405.2	218.1
Net income	$ 2,342.1	$ 2,711.7	$ 1,176.8
Net income per common share:
Basic ( in usd per share)	$ 9.09	$ 10.44	$ 4.58
Diluted (in usd per share)	$ 9.01	$ 10.29	$ 4.51
Shares used in per share calculations:
Basic (in shares)	257.7	259.8	256.7
Diluted (in shares)	259.9	263.4	260.7
Product revenues, net
Revenues:
Revenue	$ 7,573.4	$ 6,202.8	$ 4,160.7
Other revenues
Revenues:
Revenue	$ 1.0	$ 2.9	$ 2.1