Collaborative and Other Arrangements (Tables)

12 Months Ended

Dec. 31, 2021

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Schedule of Collaborative Arrangement on Research and Development

During the three years ended December 31, 2021, we recognized the following amounts in total related to these agreements:

	2021		2020		2019
	(in millions)
Total research and development expenses incurred under the Original CTX001 JDCA and A&R JDCA	$	230.4	$	101.2	$	60.3
Vertex’s share recognized in “Research and development expenses” in consolidated statements of operations	129.0		50.6		30.1