Collaborative Arrangements - Aggregate VIE Financial Information (Details) - USD ($) $ in Thousands	3 Months Ended									12 Months Ended
	Dec. 31, 2019	Sep. 30, 2019	Jun. 30, 2019	Mar. 31, 2019	Dec. 31, 2018	Sep. 30, 2018	Jun. 30, 2018	Mar. 31, 2018	Sep. 30, 2017	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Variable Interest Entity, Primary Beneficiary, Does Not Hold Majority Voting Interest, Disclosures [Abstract]
Provision for (benefit from) income taxes	$ 93,716	$ 13,148	$ 59,711	$ 51,534	$ (1,492,599)	$ 8,055	$ 10,341	$ (12,659)		$ 218,109	$ (1,486,862)	$ (107,324)
(Increase) decrease in fair value of contingent payments	$ (1,500)	$ (2,959)	$ 0	$ 0						(4,459)	0	0
Net loss attributable to noncontrolling interest					$ 25,431	$ 290	$ 1,110	$ (17,038)		$ 0	9,793	171,849
Parion Sciences, Inc
Variable Interest Entity, Primary Beneficiary, Does Not Hold Majority Voting Interest, Disclosures [Abstract]
Provision for (benefit from) income taxes									$ (126,200)
(Increase) decrease in fair value of contingent payments									$ 69,600
BioAxone Biosciences, Inc
Schedule of Collaborative Arrangement Agreements [Line Items]
Up-front payment											10,000
Variable Interest Entity, Primary Beneficiary
Variable Interest Entity, Primary Beneficiary, Does Not Hold Majority Voting Interest, Disclosures [Abstract]
Loss attributable to noncontrolling interest before benefit from income taxes and changes in fair value of contingent payments											31,191	223,379
Provision for (benefit from) income taxes											(3,668)	(114,090)
(Increase) decrease in fair value of contingent payments											(17,730)	62,560
Net loss attributable to noncontrolling interest											$ 9,793	171,849
Variable Interest Entity, Primary Beneficiary | Parion Sciences, Inc
Variable Interest Entity, Primary Beneficiary, Does Not Hold Majority Voting Interest, Disclosures [Abstract]
Provision for (benefit from) income taxes												$ 14,800