Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Current assets:
Cash and cash equivalents	$ 2,893,885	$ 2,650,134
Marketable securities	584,150	518,108
Accounts receivable, net	438,297	409,688
Inventories	136,698	124,360
Prepaid expenses and other current assets	130,009	140,819
Total current assets	4,183,039	3,843,109
Property and equipment, net	742,559	812,005
Goodwill	50,384	50,384
Deferred tax assets	1,467,518	1,499,672
Operating lease assets	60,573
Other assets	39,041	40,728
Total assets	6,543,114	6,245,898
Current liabilities:
Accounts payable	82,262	110,987
Accrued expenses	532,745	604,495
Early access sales accrual	382,703	354,404
Other current liabilities	108,758
Other current liabilities		50,406
Total current liabilities	1,106,468	1,120,292
Long-term finance lease liabilities	560,381
Long-term finance lease liabilities		581,550
Long-term operating lease liabilities	63,484
Long-term advance from collaborator	83,471	82,573
Other long-term liabilities	5,997	26,280
Total liabilities	1,819,801	1,810,695
Commitments and contingencies	0	0
Shareholders’ equity:
Preferred stock, $0.01 par value; 1,000 shares authorized; none issued and outstanding	0	0
Common stock, $0.01 par value; 500,000 shares authorized, 256,351 and 255,172 shares issued and outstanding, respectively	2,561	2,546
Additional paid-in capital	7,475,909	7,421,476
Accumulated other comprehensive income	6,000	659
Accumulated deficit	(2,761,157)	(2,989,478)
Total shareholders’ equity	4,723,313	4,435,203
Total liabilities and shareholders’ equity	$ 6,543,114	$ 6,245,898