Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Revenues:
Revenues	$ 858,435	$ 640,799
Costs and expenses:
Cost of sales	95,092	71,613
Research and development expenses	339,490	310,553
Sales, general and administrative expenses	147,045	129,808
Restructuring income	0	(76)
Total costs and expenses	581,627	511,898
Income from operations	276,808	128,901
Interest income	15,615	5,789
Interest expense	(14,868)	(16,886)
Other income, net	42,610	96,838
Income before provision for (benefit from) income taxes	320,165	214,642
Provision for (benefit from) income taxes	51,534	(12,659)
Net income	268,631	227,301
Income attributable to noncontrolling interest	0	(17,038)
Net income attributable to Vertex	$ 268,631	$ 210,263
Net income:
Basic (in dollars per share)	$ 1.05	$ 0.83
Diluted (in dollars per share)	$ 1.03	$ 0.81
Shares used in per share calculations:
Basic (in shares)	255,695	253,231
Diluted (in shares)	260,175	258,526
Product revenues, net
Revenues:
Revenues	$ 857,253	$ 637,729
Collaborative and royalty revenues
Revenues:
Revenues	$ 1,182	$ 3,070