Stock-based Compensation Expense and Share Repurchase - (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Stock-based compensation expense:
Stock-based compensation expense related to inventories	$ (465)	$ (351)
Total stock-based compensation included in costs and expenses	78,136	69,439
Cost of sales
Stock-based compensation expense:
Total stock-based compensation included in costs and expenses	813	457
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation included in costs and expenses	48,488	44,837
Sales, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation included in costs and expenses	28,835	24,145
Stock options
Stock-based compensation expense:
Share-based compensation expense by type of award	26,055	26,981
Type of award:
Unrecognized Expense	$ 203,271
Weighted-average Recognition Period	2 years 9 months 15 days
Restricted stock and restricted stock units (including PSUs)
Stock-based compensation expense:
Share-based compensation expense by type of award	$ 50,418	40,745
Type of award:
Unrecognized Expense	$ 386,253
Weighted-average Recognition Period	2 years 9 months 4 days
ESPP share issuances
Stock-based compensation expense:
Share-based compensation expense by type of award	$ 2,128	$ 2,064
Type of award:
Unrecognized Expense	$ 2,117
Weighted-average Recognition Period	5 months 5 days