Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2018	Dec. 31, 2017
Current assets:
Cash and cash equivalents	$ 1,995,893	$ 1,665,412
Marketable securities	481,124	423,254
Restricted cash and cash equivalents (VIE)	9,573	1,489
Accounts receivable, net	327,294	281,343
Inventories	117,346	111,830
Prepaid expenses and other current assets	109,886	165,635
Total current assets	3,041,116	2,648,963
Property and equipment, net	800,670	789,437
Intangible assets	29,000	29,000
Goodwill	50,384	50,384
Other assets	31,804	28,230
Total assets	3,952,974	3,546,014
Current liabilities:
Accounts payable	74,062	73,994
Accrued expenses	411,231	443,961
Capital lease obligations, current portion	16,919	22,531
Early access sales accrual	268,446	232,401
Other liabilities, current portion	56,654	34,373
Total current liabilities	827,312	807,260
Capital lease obligations, excluding current portion	16,911	20,496
Deferred tax liability	9,636	6,341
Construction financing lease obligation, excluding current portion	561,295	563,406
Advance from collaborator, excluding current portion	79,537	78,431
Other liabilities, excluding current portion	27,462	27,774
Total liabilities	1,522,153	1,503,708
Commitments and contingencies
Shareholders’ equity:
Preferred stock, $0.01 par value; 1,000,000 shares authorized; none issued and outstanding	0	0
Common stock, $0.01 par value; 500,000,000 shares authorized; 254,934,949 and 253,253,362 shares issued; and 254,867,865 and 253,253,362 shares outstanding, respectively	2,541	2,512
Additional paid-in capital	7,314,369	7,157,362
Accumulated other comprehensive loss	(39,743)	(11,572)
Accumulated deficit	(4,876,111)	(5,119,723)
Total Vertex shareholders’ equity	2,401,056	2,028,579
Noncontrolling interest	29,765	13,727
Total shareholders’ equity	2,430,821	2,042,306
Total liabilities and shareholders’ equity	$ 3,952,974	$ 3,546,014