Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Revenues:
Product revenues, net	$ 637,729	$ 480,622
Royalty revenues	1,356	1,551
Collaborative revenues	1,714	232,545
Total revenues	640,799	714,718
Costs and expenses:
Cost of sales	71,613	46,988
Research and development expenses	310,553	273,563
Sales, general and administrative expenses	129,808	113,326
Restructuring (income) expenses	(76)	9,999
Total costs and expenses	511,898	443,876
Income from operations	128,901	270,842
Interest expense, net	(11,097)	(16,765)
Other income (expense), net	96,838	(544)
Income before (benefit from) provision for income taxes	214,642	253,533
(Benefit from) provision for income taxes	(12,659)	3,985
Net income	227,301	249,548
Income attributable to noncontrolling interest	(17,038)	(1,792)
Net income attributable to Vertex	$ 210,263	$ 247,756
Net income:
Basic (in dollars per share)	$ 0.83	$ 1.01
Diluted (in dollars per share)	$ 0.81	$ 0.99
Shares used in per share calculations:
Basic (in shares)	253,231	246,024
Diluted (in shares)	258,526	248,700