Stock-based Compensation Expense - (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016
Stock-based compensation expense:
Less stock-based compensation expense capitalized to inventories	$ (1,364)	$ (955)	$ (3,657)	$ (2,728)
Total stock-based compensation included in costs and expenses	73,770	61,209	215,334	178,623
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation included in costs and expenses	46,186	39,980	134,855	115,068
Sales, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation included in costs and expenses	27,584	21,229	80,479	63,555
Stock options
Stock-based compensation expense:
Share-based compensation expense by type of award	25,969	28,773	80,865	86,859
Type of award:
Unrecognized Expense	175,298		$ 175,298
Weighted-average Recognition Period			2 years 7 months 6 days
Restricted stock and restricted stock units
Stock-based compensation expense:
Share-based compensation expense by type of award	46,737	30,966	$ 131,388	88,107
Type of award:
Unrecognized Expense	289,008		$ 289,008
Weighted-average Recognition Period			2 years 7 months 21 days
ESPP share issuances
Stock-based compensation expense:
Share-based compensation expense by type of award	2,428	$ 2,425	$ 6,738	$ 6,385
Type of award:
Unrecognized Expense	$ 2,636		$ 2,636
Weighted-average Recognition Period			5 months 16 days