Collaborative Arrangements and Acquisitions - Aggregate VIE Financial Information, Contingent Consideration Liability (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016	Dec. 31, 2016
Variable Interest Entity, Primary Beneficiary
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Decrease (increase) in fair value of contingent payments	$ 69,550	$ (1,200)	$ 62,560	$ (59,350)
Parion Sciences, Inc.
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Decrease (increase) in fair value of contingent payments	69,600
Parion Sciences, Inc. | Variable Interest Entity, Primary Beneficiary
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Decrease (increase) in fair value of contingent payments	69,550	(1,100)	63,460	(58,500)
Contingent consideration, liability	0		0		$ 238,800
BioAxone Biosciences Inc. | Variable Interest Entity, Primary Beneficiary
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Decrease (increase) in fair value of contingent payments	0	$ (100)	(900)	$ (850)
Contingent consideration, liability	$ 18,900		$ 18,900		$ 18,000