Condensed Consolidated Statements of Operations (unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2017	Jun. 30, 2016	Jun. 30, 2017	Jun. 30, 2016
Revenues:
Product revenues, net	$ 513,988	$ 425,651	$ 994,610	$ 820,061
Royalty revenues	2,861	5,282	4,412	8,878
Collaborative revenues	27,286	675	259,831	749
Total revenues	544,135	431,608	1,258,853	829,688
Costs and expenses:
Cost of product revenues	70,535	44,154	116,777	93,943
Royalty expenses	670	1,098	1,416	1,958
Research and development expenses	289,451	271,008	563,014	526,868
Sales, general and administrative expenses	127,249	111,652	240,575	216,866
Restructuring expenses, net	3,523	343	13,522	1,030
Total costs and expenses	491,428	428,255	935,304	840,665
Income (loss) from operations	52,707	3,353	323,549	(10,977)
Interest expense, net	(14,664)	(20,155)	(31,429)	(40,853)
Other (expenses) income, net	(2,537)	(1,219)	(3,081)	3,192
Income (loss) before provision for income taxes	35,506	(18,021)	289,039	(48,638)
Provision for income taxes	4,337	18,130	8,322	23,615
Net income (loss)	31,169	(36,151)	280,717	(72,253)
Income attributable to noncontrolling interest	(13,173)	(28,374)	(14,965)	(33,903)
Net income (loss) attributable to Vertex	$ 17,996	$ (64,525)	$ 265,752	$ (106,156)
Net income (loss):
Basic (in dollars per share)	$ 0.07	$ (0.26)	$ 1.08	$ (0.43)
Diluted (in dollars per share)	$ 0.07	$ (0.26)	$ 1.06	$ (0.43)
Shares used in per share calculations:
Basic (in shares)	247,521	244,482	246,782	244,124
Diluted (in shares)	251,635	244,482	250,199	244,124