Collaborative Arrangements and Pending Acquisition - Aggregate VIE Financial Information (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016	Dec. 31, 2016	Dec. 31, 2015	Jun. 30, 2015	Dec. 31, 2014
Variable Interest Entity, Primary Beneficiary, Does Not Hold Majority Voting Interest, Disclosures [Abstract]
Provision for income taxes	$ (3,985)	$ (5,485)
Net income attributable to noncontrolling interest	(1,792)	(5,529)
Variable Interest Entity, Consolidated, Carrying Amount, Assets and Liabilities, Net:
Restricted cash and cash equivalents (VIE)	44,564		$ 47,762
Prepaid expenses and other current assets	128,493		70,534
Intangible assets	284,340		284,340
Goodwill	50,384		50,384
Other assets	11,494		11,885
Accounts payable	63,145		61,451
Other current liabilities	277,962		315,249
Deferred tax liability, net	135,402		134,063
Other liabilities	28,467		28,699
Noncontrolling interest	182,785		181,609
BioAxone Biosciences Inc
Variable Interest Entity, Primary Beneficiary, Does Not Hold Majority Voting Interest, Disclosures [Abstract]
Contingent consideration, liability	18,900		18,000
Parion Sciences, Inc
Variable Interest Entity, Primary Beneficiary, Does Not Hold Majority Voting Interest, Disclosures [Abstract]
Provision for income taxes	(400)	(3,100)
Contingent consideration, liability	241,600		238,800
Variable Interest Entity, Consolidated, Carrying Amount, Assets and Liabilities, Net:
Intangible assets					$ 255,300
Variable Interest Entity, Primary Beneficiary
Variable Interest Entity, Primary Beneficiary, Does Not Hold Majority Voting Interest, Disclosures [Abstract]
Loss attributable to noncontrolling interest before provision for income taxes	1,547	839
Provision for income taxes	391	3,062
(Increase) decrease in fair value of contingent milestone and royalty payments	(3,730)	(9,430)
Net income attributable to noncontrolling interest	(1,792)	(5,529)
Variable Interest Entity, Consolidated, Carrying Amount, Assets and Liabilities, Net:
Restricted cash and cash equivalents (VIE)	44,564		47,762
Prepaid expenses and other current assets	5,957		6,812
Intangible assets	284,340		284,340
Goodwill	19,391		19,391
Other assets	687		399
Accounts payable	1,080		415
Taxes payable	1,159		1,330
Other current liabilities	1,998		2,137
Deferred tax liability, net	133,058		131,446
Other liabilities	300		300
Noncontrolling interest	182,785		$ 181,609
Variable Interest Entity, Primary Beneficiary | BioAxone Biosciences Inc
Variable Interest Entity, Primary Beneficiary, Does Not Hold Majority Voting Interest, Disclosures [Abstract]
(Increase) decrease in fair value of contingent milestone and royalty payments	(900)	(430)
Variable Interest Entity, Consolidated, Carrying Amount, Assets and Liabilities, Net:
Intangible assets						$ 29,000
Variable Interest Entity, Primary Beneficiary | Parion Sciences, Inc
Variable Interest Entity, Primary Beneficiary, Does Not Hold Majority Voting Interest, Disclosures [Abstract]
(Increase) decrease in fair value of contingent milestone and royalty payments	$ (2,830)	$ (9,000)
Variable Interest Entity, Consolidated, Carrying Amount, Assets and Liabilities, Net:
Intangible assets				$ 255,300