Fair Value Measurements (Details) - USD ($) $ in Thousands	Dec. 31, 2016	Dec. 31, 2015
Financial instruments carried at fair value (asset position):
Fair value of the term loan	$ 300,000
Level 1 \| Variable Interest Entity, Primary Beneficiary \| BioAxone Biosciences, Inc
Financial instruments carried at fair value (asset position):
Cash and cash equivalents	46,100
Level 3
Financial instruments carried at fair value (asset position):
Loans payable, fair value disclosure	300,000
Recurring basis
Financial instruments carried at fair value (asset position):
Total financial assets	546,765	$ 665,383
Total financial liabilities	144	901
Recurring basis \| Money market funds
Financial instruments carried at fair value (asset position):
Cash equivalents:	280,560	199,507
Recurring basis \| Government-sponsored enterprise securities
Financial instruments carried at fair value (asset position):
Cash equivalents:		85,994
Marketable securities:	15,508	87,162
Recurring basis \| Corporate equity securities
Financial instruments carried at fair value (asset position):
Marketable securities:	64,560
Recurring basis \| Commercial paper
Financial instruments carried at fair value (asset position):
Cash equivalents:		34,889
Marketable securities:	59,404	99,123
Recurring basis \| Corporate debt securities
Financial instruments carried at fair value (asset position):
Cash equivalents:		11,533
Marketable securities:	111,140	141,409
Recurring basis \| Prepaid and other current assets \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Prepaid and other current assets:	14,407	5,161
Recurring basis \| Other assets \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other assets:	1,186	605
Recurring basis \| Other liabilities, current portion \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other liabilities, current portion:	(144)	(769)
Recurring basis \| Other liabilities, excluding current portion \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other liabilities, excluding current portion:		(132)
Recurring basis \| Level 1
Financial instruments carried at fair value (asset position):
Total financial assets	360,628	372,663
Total financial liabilities	0	0
Recurring basis \| Level 1 \| Money market funds
Financial instruments carried at fair value (asset position):
Cash equivalents:	280,560	199,507
Recurring basis \| Level 1 \| Government-sponsored enterprise securities
Financial instruments carried at fair value (asset position):
Cash equivalents:		85,994
Marketable securities:	15,508	87,162
Recurring basis \| Level 1 \| Corporate equity securities
Financial instruments carried at fair value (asset position):
Marketable securities:	64,560
Recurring basis \| Level 1 \| Commercial paper
Financial instruments carried at fair value (asset position):
Cash equivalents:		0
Marketable securities:	0	0
Recurring basis \| Level 1 \| Corporate debt securities
Financial instruments carried at fair value (asset position):
Cash equivalents:		0
Marketable securities:	0	0
Recurring basis \| Level 1 \| Prepaid and other current assets \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Prepaid and other current assets:	0	0
Recurring basis \| Level 1 \| Other assets \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other assets:	0	0
Recurring basis \| Level 1 \| Other liabilities, current portion \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other liabilities, current portion:	0	0
Recurring basis \| Level 1 \| Other liabilities, excluding current portion \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other liabilities, excluding current portion:		0
Recurring basis \| Level 2
Financial instruments carried at fair value (asset position):
Total financial assets	186,137	292,720
Total financial liabilities	144	901
Recurring basis \| Level 2 \| Money market funds
Financial instruments carried at fair value (asset position):
Cash equivalents:	0	0
Recurring basis \| Level 2 \| Government-sponsored enterprise securities
Financial instruments carried at fair value (asset position):
Cash equivalents:		0
Marketable securities:	0	0
Recurring basis \| Level 2 \| Corporate equity securities
Financial instruments carried at fair value (asset position):
Marketable securities:	0
Recurring basis \| Level 2 \| Commercial paper
Financial instruments carried at fair value (asset position):
Cash equivalents:		34,889
Marketable securities:	59,404	99,123
Recurring basis \| Level 2 \| Corporate debt securities
Financial instruments carried at fair value (asset position):
Cash equivalents:		11,533
Marketable securities:	111,140	141,409
Recurring basis \| Level 2 \| Prepaid and other current assets \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Prepaid and other current assets:	14,407	5,161
Recurring basis \| Level 2 \| Other assets \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other assets:	1,186	605
Recurring basis \| Level 2 \| Other liabilities, current portion \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other liabilities, current portion:	(144)	(769)
Recurring basis \| Level 2 \| Other liabilities, excluding current portion \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other liabilities, excluding current portion:		(132)
Recurring basis \| Level 3
Financial instruments carried at fair value (asset position):
Total financial assets	0	0
Total financial liabilities	0	0
Recurring basis \| Level 3 \| Money market funds
Financial instruments carried at fair value (asset position):
Cash equivalents:	0	0
Recurring basis \| Level 3 \| Government-sponsored enterprise securities
Financial instruments carried at fair value (asset position):
Cash equivalents:		0
Marketable securities:	0	0
Recurring basis \| Level 3 \| Corporate equity securities
Financial instruments carried at fair value (asset position):
Marketable securities:	0
Recurring basis \| Level 3 \| Commercial paper
Financial instruments carried at fair value (asset position):
Cash equivalents:		0
Marketable securities:	0	0
Recurring basis \| Level 3 \| Corporate debt securities
Financial instruments carried at fair value (asset position):
Cash equivalents:		0
Marketable securities:	0	0
Recurring basis \| Level 3 \| Prepaid and other current assets \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Prepaid and other current assets:	0	0
Recurring basis \| Level 3 \| Other assets \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other assets:	0	0
Recurring basis \| Level 3 \| Other liabilities, current portion \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other liabilities, current portion:	$ 0	0
Recurring basis \| Level 3 \| Other liabilities, excluding current portion \| Foreign currency forward contracts
Financial instruments carried at fair value (asset position):
Other liabilities, excluding current portion:		$ 0

Fair value portion of probable future economic benefits obtained or controlled by an entity as a result of past transactions or events.

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