Collaborative Arrangements - BioAxone Biosciences, Inc. (Details) - BioAxone Biosciences, Inc - USD ($)	1 Months Ended	3 Months Ended	12 Months Ended
	Oct. 31, 2014	Dec. 31, 2014	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Decrease (increase) in fair value of contingent payments			$ 10,000,000	$ (900,000)	$ (500,000)
Up-front payment		$ 10,000,000
Maximum license fees and milestone payments	$ 90,000,000.0
In-process research and development intangible assets	29,000,000
Deferred tax liability attributable to BioAxone	$ 11,300,000
Purchase option, term of extension of expiration date	1 year
Contingent consideration liability			$ 18,000,000	$ 28,000,000