Segment Information (Tables)

12 Months Ended

Dec. 31, 2016

Segment Reporting [Abstract]

Revenues by Product

Product revenues, net consisted of the following:

	2016		2015		2014
	(in thousands)
KALYDECO	$	703,432	$	631,674	$	463,750
ORKAMBI	979,590		350,663		—
INCIVEK	610		17,987		24,071
Total product revenues, net	$	1,683,632	$	1,000,324	$	487,821

Revenues and Property and Equipment by Location

Property and equipment, net by location consisted of the following:

	As of December 31,
	2016		2015
	(in thousands)
United States	$	665,552	$	661,421
Outside of the United States
United Kingdom	26,921		32,793
Other	5,889		3,501
Total property and equipment, net outside of the United States	32,810		36,294
Total property and equipment, net	$	698,362	$	697,715

Total revenues from external customers and collaborators by geographic region consisted of the following. Product revenues are attributed to countries based on the location of the customer. Collaborative revenues are attributed to the operations of the Company in the United States. Royalty revenues are attributed to countries based on the location of the collaborator.

	2016		2015		2014
	(in thousands)
United States	$	1,321,807	$	763,316	$	361,074
Outside of the United States
Europe	320,456		219,596		197,611
Other	59,914		49,424		21,730
Total revenues outside of the United States	380,370		269,020		219,341
Total revenues	$	1,702,177	$	1,032,336	$	580,415

Significant Customers

Gross revenues and accounts receivable from each of the Company’s customers who individually accounted for 10% or more of total gross revenues and/or 10% or more of total gross accounts receivable consisted of the following:

	Percent of Total Gross Revenues						Percent of Gross Accounts Receivable
	Year Ended December 31,						As of December 31,
	2016		2015		2014		2016		2015
Walgreen Co.	19	%	20	%	12	%	15	%	15	%
CVS/Caremark	19	%	17	%	<10	%	17	%	17	%
Accredo/Curascript	15	%	15	%	<10	%	10	%	16	%