Stock-based Compensation Expense - (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Stock-based compensation expense:
Less stock-based compensation expense capitalized to inventories	$ (955)	$ (1,281)	$ (2,728)	$ (3,318)
Total stock-based compensation included in costs and expenses	61,209	65,734	178,623	186,379
Stock options
Stock-based compensation expense:
Stock-based compensation expense by type of award:	28,773	39,074	86,859	105,720
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	185,148		$ 185,148
Weighted-average recognition period (in years)			2 years 7 months 28 days
Restricted stock and restricted stock units
Stock-based compensation expense:
Stock-based compensation expense by type of award:	30,966	26,203	$ 88,107	78,274
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	206,336		$ 206,336
Weighted-average recognition period (in years)			2 years 6 months 26 days
ESPP share issuances
Stock-based compensation expense:
Stock-based compensation expense by type of award:	2,425	1,738	$ 6,385	5,703
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	2,886		$ 2,886
Weighted-average recognition period (in years)			5 months 19 days
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation included in costs and expenses	39,980	44,701	$ 115,068	124,550
Sales, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation included in costs and expenses	$ 21,229	$ 21,033	$ 63,555	$ 61,829