Fair Value Measurements (Details) - USD ($) $ in Thousands	Sep. 30, 2016	Dec. 31, 2015
Level 3
Financial instruments carried at fair value (liability position):
Term loan fair value	$ 297,800
Recurring basis
Financial assets carried at fair value:
Total financial assets	518,454	$ 665,383
Financial instruments carried at fair value (liability position):
Total financial liabilities	1,774	901
Recurring basis \| Money market funds
Financial assets carried at fair value:
Cash equivalents	101,844	199,507
Recurring basis \| Commercial paper
Financial assets carried at fair value:
Cash equivalents		34,889
Marketable securities	131,376	99,123
Recurring basis \| Government-sponsored enterprise securities
Financial assets carried at fair value:
Cash equivalents		85,994
Marketable securities	130,431	87,162
Recurring basis \| Corporate debt securities
Financial assets carried at fair value:
Cash equivalents		11,533
Marketable securities	146,942	141,409
Recurring basis \| Level 1
Financial assets carried at fair value:
Total financial assets	232,275	372,663
Financial instruments carried at fair value (liability position):
Total financial liabilities	0	0
Recurring basis \| Level 1 \| Money market funds
Financial assets carried at fair value:
Cash equivalents	101,844	199,507
Recurring basis \| Level 1 \| Commercial paper
Financial assets carried at fair value:
Cash equivalents		0
Marketable securities	0	0
Recurring basis \| Level 1 \| Government-sponsored enterprise securities
Financial assets carried at fair value:
Cash equivalents		85,994
Marketable securities	130,431	87,162
Recurring basis \| Level 1 \| Corporate debt securities
Financial assets carried at fair value:
Cash equivalents		0
Marketable securities	0	0
Recurring basis \| Level 2
Financial assets carried at fair value:
Total financial assets	286,179	292,720
Financial instruments carried at fair value (liability position):
Total financial liabilities	1,774	901
Recurring basis \| Level 2 \| Money market funds
Financial assets carried at fair value:
Cash equivalents	0	0
Recurring basis \| Level 2 \| Commercial paper
Financial assets carried at fair value:
Cash equivalents		34,889
Marketable securities	131,376	99,123
Recurring basis \| Level 2 \| Government-sponsored enterprise securities
Financial assets carried at fair value:
Cash equivalents		0
Marketable securities	0	0
Recurring basis \| Level 2 \| Corporate debt securities
Financial assets carried at fair value:
Cash equivalents		11,533
Marketable securities	146,942	141,409
Recurring basis \| Level 3
Financial assets carried at fair value:
Total financial assets	0	0
Financial instruments carried at fair value (liability position):
Total financial liabilities	0	0
Recurring basis \| Level 3 \| Money market funds
Financial assets carried at fair value:
Cash equivalents	0	0
Recurring basis \| Level 3 \| Commercial paper
Financial assets carried at fair value:
Cash equivalents		0
Marketable securities	0	0
Recurring basis \| Level 3 \| Government-sponsored enterprise securities
Financial assets carried at fair value:
Cash equivalents		0
Marketable securities	0	0
Recurring basis \| Level 3 \| Corporate debt securities
Financial assets carried at fair value:
Cash equivalents		0
Marketable securities	0	0
Prepaid and other current assets \| Foreign currency forward contracts \| Recurring basis
Financial assets carried at fair value:
Foreign currency forward contracts	7,644	5,161
Prepaid and other current assets \| Foreign currency forward contracts \| Recurring basis \| Level 1
Financial assets carried at fair value:
Foreign currency forward contracts	0	0
Prepaid and other current assets \| Foreign currency forward contracts \| Recurring basis \| Level 2
Financial assets carried at fair value:
Foreign currency forward contracts	7,644	5,161
Prepaid and other current assets \| Foreign currency forward contracts \| Recurring basis \| Level 3
Financial assets carried at fair value:
Foreign currency forward contracts	0	0
Other Assets \| Foreign currency forward contracts \| Recurring basis
Financial assets carried at fair value:
Foreign currency forward contracts	217	605
Other Assets \| Foreign currency forward contracts \| Recurring basis \| Level 1
Financial assets carried at fair value:
Foreign currency forward contracts	0	0
Other Assets \| Foreign currency forward contracts \| Recurring basis \| Level 2
Financial assets carried at fair value:
Foreign currency forward contracts	217	605
Other Assets \| Foreign currency forward contracts \| Recurring basis \| Level 3
Financial assets carried at fair value:
Foreign currency forward contracts	0	0
Other liabilities, current portion \| Foreign currency forward contracts \| Recurring basis
Financial assets carried at fair value:
Foreign currency forward contracts	(1,459)
Financial instruments carried at fair value (liability position):
Derivative liability current		(769)
Other liabilities, current portion \| Foreign currency forward contracts \| Recurring basis \| Level 1
Financial assets carried at fair value:
Foreign currency forward contracts	0
Financial instruments carried at fair value (liability position):
Derivative liability current		0
Other liabilities, current portion \| Foreign currency forward contracts \| Recurring basis \| Level 2
Financial assets carried at fair value:
Foreign currency forward contracts	(1,459)
Financial instruments carried at fair value (liability position):
Derivative liability current		(769)
Other liabilities, current portion \| Foreign currency forward contracts \| Recurring basis \| Level 3
Financial assets carried at fair value:
Foreign currency forward contracts	0
Financial instruments carried at fair value (liability position):
Derivative liability current		0
Other liabilities, excluding current portion \| Foreign currency forward contracts \| Recurring basis
Financial assets carried at fair value:
Foreign currency forward contracts	(315)
Financial instruments carried at fair value (liability position):
Derivative liability noncurrent		(132)
Other liabilities, excluding current portion \| Foreign currency forward contracts \| Recurring basis \| Level 1
Financial assets carried at fair value:
Foreign currency forward contracts	0
Financial instruments carried at fair value (liability position):
Derivative liability noncurrent		0
Other liabilities, excluding current portion \| Foreign currency forward contracts \| Recurring basis \| Level 2
Financial assets carried at fair value:
Foreign currency forward contracts	(315)
Financial instruments carried at fair value (liability position):
Derivative liability noncurrent		(132)
Other liabilities, excluding current portion \| Foreign currency forward contracts \| Recurring basis \| Level 3
Financial assets carried at fair value:
Foreign currency forward contracts	0
Financial instruments carried at fair value (liability position):
Derivative liability noncurrent		$ 0
Variable Interest Entity, Primary Beneficiary \| BioAxone Biosciences Inc \| Level 1
Financial instruments carried at fair value (liability position):
Cash and cash equivalents	$ 57,900

Fair value portion of probable future economic benefits obtained or controlled by an entity as a result of past transactions or events.

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