Stock-based Compensation Expense - Stock-based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2016	Jun. 30, 2015	Jun. 30, 2016	Jun. 30, 2015
Stock-based compensation expense:
Less stock-based compensation expense capitalized to inventories	$ (928)	$ (1,153)	$ (1,773)	$ (2,037)
Total stock-based compensation included in costs and expenses	61,942	63,261	117,414	120,645
Stock options
Stock-based compensation expense:
Stock-based compensation expense by type of award:	31,826	37,687	58,086	66,646
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	176,251		$ 176,251
Weighted-average recognition period (in years)			2 years 7 months 28 days
Restricted stock and restricted stock units
Stock-based compensation expense:
Stock-based compensation expense by type of award:	29,608	24,902	$ 57,141	52,071
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	201,858		$ 201,858
Weighted-average recognition period (in years)			2 years 6 months 26 days
ESPP share issuances
Stock-based compensation expense:
Stock-based compensation expense by type of award:	1,436	1,825	$ 3,960	3,965
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	5,546		$ 5,546
Weighted-average recognition period (in years)			7 months 21 days
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation included in costs and expenses	40,640	41,632	$ 75,088	79,849
Sales, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation included in costs and expenses	$ 21,302	$ 21,629	$ 42,326	$ 40,796