Additional Balance Sheet Detail (Details) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Other Liabilities, Current
Deferred rent	$ 1,572	$ 4,015
Security deposits	4,000	0
Fair value foreign currency forward contracts	5,161	2,011
Other liabilities, current portion	14,374	4,797
Other	1,702	485
Prepaid Expense and Other Assets, Current
Prepaid expenses	22,058	17,569
Taxes receivable	11,651	14,093
Deferred tax asset	0	3,500
Other	12,065	7,002
Total	50,935	44,175
Accrued expenses
Payroll and benefits	87,873	91,175
Research, development and commercial contract costs	55,677	38,143
Product revenue allowances	47,209	34,554
Royalty payable	60,191	12,218
Taxes payable and reserves (including VIE taxes payable)	30,953	10,038
Professional fees	7,455	7,004
Interest	4,642	5,444
Other	11,820	11,100
Total	305,820	209,676
Variable Interest Entity, Primary Beneficiary
Other Liabilities, Current
Other liabilities, current portion	7,100	297
Prepaid Expense and Other Assets, Current
Total	3,138	268
Accrued expenses
Total	$ 7,100	$ 297