Collaborative Arrangements - Aggregate VIE FInancial Information (Details) - USD ($) $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2015	Sep. 30, 2015	Jun. 30, 2015	Mar. 31, 2015	Dec. 31, 2014	Sep. 30, 2014	Jun. 30, 2014	Mar. 31, 2014	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Jun. 04, 2015
Variable Interest Entity, Primary Beneficiary, Does Not Hold Majority Voting Interest, Disclosures [Abstract]
Loss attributable to noncontrolling interest before provision for income taxes									$ 31,847	$ 4,190	$ 0
Provision for (benefit from) income taxes	$ (1,379)	$ 1,330	$ 30,131	$ 299	$ 2,043	$ 3,419	$ 693	$ 803	30,381	6,958	(122,422)
Net loss attributable to noncontrolling interest	938	$ (1,333)	$ 32,144	$ 98
Variable Interest Entity, Consolidated, Carrying Amount, Assets and Liabilities, Net:
Restricted cash and cash equivalents (VIE)	78,910				8,418				78,910	8,418
Prepaid expenses and other current assets	50,935				44,175				50,935	44,175
Intangible assets	284,340				29,000				284,340	29,000
Goodwill	50,384				39,915				50,384	39,915
Other assets	7,200				3,265				7,200	3,265
Accounts payable	74,942				71,194				74,942	71,194
Other current liabilities	305,820				209,676				305,820	209,676
Deferred tax liability	110,439				15,044				110,439	15,044
Other liabilities	31,778				21,707				31,778	21,707
Noncontrolling interest	153,661				21,177				153,661	21,177
BioAxone Biosciences, Inc
Variable Interest Entity, Primary Beneficiary, Does Not Hold Majority Voting Interest, Disclosures [Abstract]
(Increase) decrease in fair value of contingent milestone and royalty payments									(900)	(500)
Contingent consideration liability	28,000				27,100				28,000	27,100
Variable Interest Entity, Consolidated, Carrying Amount, Assets and Liabilities, Net:
Deferred tax liability	110,400				11,500				110,400	11,500
Parion Sciences, Inc
Variable Interest Entity, Primary Beneficiary, Does Not Hold Majority Voting Interest, Disclosures [Abstract]
(Increase) decrease in fair value of contingent milestone and royalty payments									(3,600)
Contingent consideration liability	179,000								179,000
Variable Interest Entity, Consolidated, Carrying Amount, Assets and Liabilities, Net:
Intangible assets												$ 255,340
Goodwill												10,468
Deferred tax liability												91,023
Variable Interest Entity, Primary Beneficiary
Variable Interest Entity, Primary Beneficiary, Does Not Hold Majority Voting Interest, Disclosures [Abstract]
Loss attributable to noncontrolling interest before provision for income taxes									6,646	764	283,747
Provision for (benefit from) income taxes									29,731	3,876	(166,145)
(Increase) decrease in fair value of contingent milestone and royalty payments									(4,530)	(450)	124,920
Net loss attributable to noncontrolling interest									31,847	4,190	$ 242,522
Variable Interest Entity, Consolidated, Carrying Amount, Assets and Liabilities, Net:
Restricted cash and cash equivalents (VIE)	78,910				8,418				78,910	8,418
Prepaid expenses and other current assets	3,138				268				3,138	268
Intangible assets	284,340				29,000				284,340	29,000
Goodwill	19,391				8,923				19,391	8,923
Other assets	455				42				455	42
Accounts payable	676				189				676	189
Taxes payable	24,554				3,594				24,554	3,594
Other current liabilities	7,100				297				7,100	297
Deferred tax liability	110,438				11,544				110,438	11,544
Other liabilities	300				300				300	300
Noncontrolling interest	$ 153,661				$ 21,177				$ 153,661	$ 21,177
Variable Interest Entity, Primary Beneficiary | Parion Sciences, Inc
Variable Interest Entity, Consolidated, Carrying Amount, Assets and Liabilities, Net:
Intangible assets												$ 255,300