Nature of Business and Accounting Policies - Revenue Recognition (Details) - USD ($)	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Activity related to product revenues allowances and reserve categories
Beginning Balance	$ 36,023,000	$ 87,133,000	$ 75,393,000
Provision related to current period sales	81,205,000	48,006,000	250,944,000
Adjustments related to prior period sales	(20,852,000)	3,270,000	19,738,000
Credits/payments made	(47,080,000)	(102,386,000)	(258,942,000)
Ending Balance	49,296,000	36,023,000	87,133,000
INCIVEK
Activity related to product revenues allowances and reserve categories
Accrual for for government rebates (less than)	1,000,000
Trade Allowances
Activity related to product revenues allowances and reserve categories
Beginning Balance	1,463,000	1,535,000	5,416,000
Provision related to current period sales	10,890,000	8,468,000	31,395,000
Adjustments related to prior period sales	(214,000)	(43,000)	343,000
Credits/payments made	(10,050,000)	(8,497,000)	(35,619,000)
Ending Balance	2,089,000	1,463,000	1,535,000
Rebates, Chargebacks and Discounts
Activity related to product revenues allowances and reserve categories
Beginning Balance	29,102,000	68,244,000	63,560,000
Provision related to current period sales	65,781,000	35,713,000	204,459,000
Adjustments related to prior period sales	(19,410,000)	329,000	4,474,000
Credits/payments made	(30,804,000)	(75,184,000)	(204,249,000)
Ending Balance	44,669,000	29,102,000	68,244,000
Product Returns
Activity related to product revenues allowances and reserve categories
Beginning Balance	4,713,000	15,799,000	2,852,000
Provision related to current period sales	779,000	2,478,000	5,795,000
Adjustments related to prior period sales	(993,000)	3,056,000	15,149,000
Credits/payments made	(3,271,000)	(16,620,000)	(7,997,000)
Ending Balance	1,228,000	4,713,000	15,799,000
Other Incentives
Activity related to product revenues allowances and reserve categories
Beginning Balance	745,000	1,555,000	3,565,000
Provision related to current period sales	3,755,000	1,347,000	9,295,000
Adjustments related to prior period sales	(235,000)	(72,000)	(228,000)
Credits/payments made	(2,955,000)	(2,085,000)	(11,077,000)
Ending Balance	$ 1,310,000	$ 745,000	$ 1,555,000