Stock-based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2015	Jun. 30, 2014	Jun. 30, 2015	Jun. 30, 2014
Stock-based compensation expense:
Less stock-based compensation expense capitalized to inventories	$ (1,153)	$ (242)	$ (2,037)	$ (449)
Total stock-based compensation included in costs and expenses	63,261	42,444	120,645	89,024
Stock options
Stock-based compensation expense:
Stock-based compensation expense by type of award	37,687	26,985	66,646	52,112
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	169,671		$ 169,671
Weighted-average recognition period (in years)			2 years 2 months 19 days
Restricted stock and restricted stock units
Stock-based compensation expense:
Stock-based compensation expense by type of award	24,902	14,020	$ 52,071	33,013
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	175,285		$ 175,285
Weighted-average recognition period (in years)			2 years 8 months 23 days
ESPP share issuances
Stock-based compensation expense:
Stock-based compensation expense by type of award	1,825	1,681	$ 3,965	4,348
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	3,953		$ 3,953
Weighted-average recognition period (in years)			7 months 2 days
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation included in costs and expenses	41,632	27,253	$ 79,849	60,153
Sales, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation included in costs and expenses	$ 21,629	$ 15,191	$ 40,796	$ 28,871
Stock and Option Plan 2013 [Member]
Type of award:
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized	7,800,000