Stock-based Compensation Expense (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended
	Mar. 31, 2015	Mar. 31, 2014
Stock-based compensation expense:
Less stock-based compensation expense capitalized to inventories	$ (884)	$ (207)
Total stock-based compensation included in costs and expenses	57,384	46,580
Stock options
Stock-based compensation expense:
Stock-based compensation expense by type of award	28,959	25,127
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	199,256
Weighted-average Recognition Period (in years)	2 years 3 months 22 days
Restricted stock and restricted stock units
Stock-based compensation expense:
Stock-based compensation expense by type of award	27,169	18,993
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	201,465
Weighted-average Recognition Period (in years)	2 years 10 months 17 days
ESPP share issuances
Stock-based compensation expense:
Stock-based compensation expense by type of award	2,140	2,667
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	2,205
Weighted-average Recognition Period (in years)	5 months 12 days
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation included in costs and expenses	38,217	32,900
Sales, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation included in costs and expenses	$ 19,167	$ 13,680
Maximum
Share-based Compensation Arrangement by Share-based Payment Award
Maximum percent of employees eligible for partial or full acceleration of equity awards	5.00%