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Common Stock, Preferred Stock and Equity Plans (Details) (USD $)
12 Months Ended
Dec. 31, 2014
vote
Dec. 31, 2013
Dec. 31, 2012
Share-based Compensation Arrangement by Share-based Payment Award      
Common stock, shares authorized 300,000,000us-gaap_CommonStockSharesAuthorized 300,000,000us-gaap_CommonStockSharesAuthorized  
Common stock, votes per share (votes per share) 1vrtx_CommonStockVotesPerShare    
Preferred stock, shares authorized 1,000,000us-gaap_PreferredStockSharesAuthorized 1,000,000us-gaap_PreferredStockSharesAuthorized  
Preferred stock, shares issued 0us-gaap_PreferredStockSharesIssued 0us-gaap_PreferredStockSharesIssued  
Preferred stock, shares outstanding 0us-gaap_PreferredStockSharesOutstanding 0us-gaap_PreferredStockSharesOutstanding  
Awards Outstanding (shares) 14,909,805vrtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOutstandingNumber    
Additional awards authorized for grant (shares) 10,552,371us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant    
Grant price of outstanding restricted stock and restricted stock units (usd per share)   $ 0.01vrtx_OutstandingRestrictedStockAndRestrictedStockUnitsGrantPrice $ 0.01vrtx_OutstandingRestrictedStockAndRestrictedStockUnitsGrantPrice
Stock Options      
Stock options outstanding at beginning of period (in shares) 15,729,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber    
Stock options granted (in shares) 3,614,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriod    
Stock options exercised (in shares) (6,153,000)us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised    
Stock options forfeited (in shares) (1,173,000)us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod    
Stock options expired (in shares) (14,000)us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod    
Stock options outstanding at end of period (in shares) 12,003,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber 15,729,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber  
Stock options exercisable at end of period (in shares) 5,553,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber    
Total exercisable or expected to vest, stock options (in shares) 11,380,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber    
Weighted-average Exercise Price      
Weighted-average exercise price outstanding at beginning of period (usd per share) $ 44.40us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice    
Weighted average exercise price, granted (usd per share) $ 84.33us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice    
Weighted average exercise price, exercised (usd per share) $ 41.53us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice    
Weighted average exercise price, forfeited (usd per share) $ 55.28us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice    
Weighted average exercise price, expired (usd per share) $ 66.43us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageExercisePrice    
Weighted-average exercise price outstanding at end of period (usd per share) $ 56.81us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice $ 44.40us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice  
Weighted average exercise price exercisable at the end of the period (usd per share) $ 45.61us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice    
Total exercisable or expected to vest, weighted average exercise price (usd per share) $ 55.94us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice    
Weighted-average Remaining Contractual Life      
Weighted-average Remaining Contractual Life, outstanding (in years) 6 years 11 months 8 days    
Weighted-average Remaining Contractual Life, exercisable (in years) 5 years 5 months 5 days    
Weighted-average Remaining Contractual Life, total exercisable or expected to vest (in years) 6 years 10 months 6 days    
Aggregate Intrinsic Value      
Aggregate intrinsic value, outstanding $ 761,274,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue    
Aggregate intrinsic value, exercisable 414,345,000us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1    
Aggregate intrinsic value, total exercisable or expected to vest 731,677,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue    
Total Intrinsic Value and Cash Received      
Market price (usd per share) $ 120.23vrtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardMarketPrice    
Total intrinsic value of stock options exercised 316,500,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue 291,600,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue 148,700,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue
Total cash received from employees as a result of employee stock option exercises $ 255,500,000us-gaap_EmployeeServiceShareBasedCompensationCashReceivedFromExerciseOfStockOptions $ 246,800,000us-gaap_EmployeeServiceShareBasedCompensationCashReceivedFromExerciseOfStockOptions $ 172,800,000us-gaap_EmployeeServiceShareBasedCompensationCashReceivedFromExerciseOfStockOptions
Maximum      
Share-based Compensation Arrangement by Share-based Payment Award      
Expiration period (years) 10 years    
2013 Stock and Option Plan      
Share-based Compensation Arrangement by Share-based Payment Award      
Awards Outstanding (shares) 2,857,275vrtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOutstandingNumber
/ us-gaap_PlanNameAxis
= vrtx_StockandOptionPlan2013Member
   
Additional awards authorized for grant (shares) 9,362,898us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant
/ us-gaap_PlanNameAxis
= vrtx_StockandOptionPlan2013Member
   
Additional shares authorized 9,500,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized
/ us-gaap_PlanNameAxis
= vrtx_StockandOptionPlan2013Member
   
Number of shares authorized   3,300,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized
/ us-gaap_PlanNameAxis
= vrtx_StockandOptionPlan2013Member
 
2006 Stock and Option Plan      
Share-based Compensation Arrangement by Share-based Payment Award      
Awards Outstanding (shares) 11,428,741vrtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOutstandingNumber
/ us-gaap_PlanNameAxis
= vrtx_StockAndOptionPlan2006Member
   
Additional awards authorized for grant (shares) 1,189,473us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant
/ us-gaap_PlanNameAxis
= vrtx_StockAndOptionPlan2006Member
   
Additional shares authorized     3,000,000us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized
/ us-gaap_PlanNameAxis
= vrtx_StockAndOptionPlan2006Member
1996 Stock and Option Plan      
Share-based Compensation Arrangement by Share-based Payment Award      
Awards Outstanding (shares) 623,789vrtx_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOutstandingNumber
/ us-gaap_PlanNameAxis
= vrtx_StockAndOptionPlan1996Member
   
Additional awards authorized for grant (shares) 0us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant
/ us-gaap_PlanNameAxis
= vrtx_StockAndOptionPlan1996Member
   
Restricted stock      
Share-based Compensation Arrangement by Share-based Payment Award      
Grant price of outstanding restricted stock and restricted stock units (usd per share) $ 0.01vrtx_OutstandingRestrictedStockAndRestrictedStockUnitsGrantPrice
/ us-gaap_AwardTypeAxis
= us-gaap_RestrictedStockMember
   
Restricted stock vesting period 4 years