Segment Information (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended								12 Months Ended
	Dec. 31, 2013	Sep. 30, 2013	Jun. 30, 2013	Mar. 31, 2013	Dec. 31, 2012	Sep. 30, 2012	Jun. 30, 2012	Mar. 31, 2012	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Revenues from external customers
Product revenues, net	$ 128,822	$ 186,653	$ 254,789	$ 267,381	$ 281,309	$ 303,501	$ 373,273	$ 375,375	$ 837,645	$ 1,333,458	$ 950,889
Total revenues	351,157	221,700	310,750	328,368	333,994	336,006	418,305	438,737	1,211,975	1,527,042	1,410,626
Property and equipment, net	696,911				433,609				696,911	433,609
United States
Revenues from external customers
Total revenues									896,952	1,373,516	1,389,568
Property and equipment, net	657,587				400,102				657,587	400,102
Europe [Member]
Revenues from external customers
Total revenues									279,557	129,786	20,289
Outside of the United States
Revenues from external customers
Total revenues									315,023	153,526	21,058
Property and equipment, net	39,324				33,507				39,324	33,507
United Kingdom
Revenues from external customers
Property and equipment, net	29,970				30,622				29,970	30,622
Other
Revenues from external customers
Total revenues									35,466	23,740	769
Property and equipment, net	9,354				2,885				9,354	2,885
Minimum | Revenues, Net
Revenues from external customers
Concentration risk (less than 10% for Cardinal health, Janssen and Mitsubishi Tanabe) (percentage)									10.00%	10.00%
Minimum | Accounts Receivable
Revenues from external customers
Threshold for disclosure percentage	10.00%				10.00%				10.00%	10.00%
Credit Concentration Risk | Janssen | Revenues, Net
Revenues from external customers
Concentration risk (less than 10% for Cardinal health, Janssen and Mitsubishi Tanabe) (percentage)									22.00%	10.00%	19.00%
Credit Concentration Risk | Janssen | Accounts Receivable
Revenues from external customers
Concentration risk (less than 10% for Cardinal health, Janssen and Mitsubishi Tanabe) (percentage)									28.00%	26.00%
Credit Concentration Risk | AmerisourceBergen Drug Corporation | Revenues, Net
Revenues from external customers
Concentration risk (less than 10% for Cardinal health, Janssen and Mitsubishi Tanabe) (percentage)									21.00%	32.00%	25.00%
Credit Concentration Risk | AmerisourceBergen Drug Corporation | Accounts Receivable
Revenues from external customers
Concentration risk (less than 10% for Cardinal health, Janssen and Mitsubishi Tanabe) (percentage)									10.00%	22.00%
Credit Concentration Risk | McKesson Corporation | Revenues, Net
Revenues from external customers
Concentration risk (less than 10% for Cardinal health, Janssen and Mitsubishi Tanabe) (percentage)									21.00%	29.00%	24.00%
Credit Concentration Risk | McKesson Corporation | Accounts Receivable
Revenues from external customers
Concentration risk (less than 10% for Cardinal health, Janssen and Mitsubishi Tanabe) (percentage)									10.00%	26.00%
Credit Concentration Risk | Cardinal Health Incorporated | Revenues, Net
Revenues from external customers
Concentration risk (less than 10% for Cardinal health, Janssen and Mitsubishi Tanabe) (percentage)									10.00%	15.00%	15.00%
Credit Concentration Risk | Cardinal Health Incorporated | Accounts Receivable
Revenues from external customers
Concentration risk (less than 10% for Cardinal health, Janssen and Mitsubishi Tanabe) (percentage)									10.00%	10.00%
Credit Concentration Risk | Bupa Home Healthcare Limited | Revenues, Net
Revenues from external customers
Concentration risk (less than 10% for Cardinal health, Janssen and Mitsubishi Tanabe) (percentage)									10.00%	10.00%
Credit Concentration Risk | Bupa Home Healthcare Limited | Accounts Receivable
Revenues from external customers
Concentration risk (less than 10% for Cardinal health, Janssen and Mitsubishi Tanabe) (percentage)									14.00%
INCIVEK
Revenues from external customers
Product revenues, net									466,360	1,161,813	950,889
KALYDECO
Revenues from external customers
Product revenues, net									$ 371,285	$ 171,645	$ 0