Stock-based Compensation Expense (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2013	Sep. 30, 2012	Sep. 30, 2013	Sep. 30, 2012
Stock-based compensation expense:
Less stock-based compensation expense capitalized to inventories	$ (204)	$ (339)	$ (885)	$ (888)
Total stock-based compensation expense included in costs and expenses	31,308	27,582	103,933	86,649
Stock options
Stock-based compensation expense:
Stock-based compensation expense by type of award	19,010	18,869	68,633	59,774
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	184,969		184,969
Weighted-average Recognition Period (in years)	2 years 8 months 27 days
Restricted stock and restricted stock units
Stock-based compensation expense:
Stock-based compensation expense by type of award	10,998	7,104	30,108	21,643
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	103,454		103,454
Weighted-average Recognition Period (in years)	2 years 7 months 10 days
ESPP share issuances
Stock-based compensation expense:
Stock-based compensation expense by type of award	1,504	1,948	6,077	6,120
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	830		830
Weighted-average Recognition Period (in years)	3 months 22 days
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	19,223	17,444	64,312	54,425
Sales, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	$ 12,085	$ 10,138	$ 39,621	$ 32,224