Stock-based Compensation Expense (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended		6 Months Ended
	Jun. 30, 2013	Jun. 30, 2012	Jun. 30, 2013	Jun. 30, 2012
Stock-based compensation expense:
Less stock-based compensation expense capitalized to inventories	$ (382)	$ (299)	$ (681)	$ (549)
Total stock-based compensation expense included in costs and expenses	41,350	31,379	72,625	59,067
Stock options
Stock-based compensation expense:
Stock-based compensation expense by type of award	29,949	22,683	49,623	40,905
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	162,669		162,669
Weighted-average Recognition Period (in years)	2 years 9 months 0 days
Restricted stock and restricted stock units
Stock-based compensation expense:
Stock-based compensation expense by type of award	9,732	7,253	19,110	14,539
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	78,790		78,790
Weighted-average Recognition Period (in years)	2 years 5 months 9 days
ESPP share issuances
Stock-based compensation expense:
Stock-based compensation expense by type of award	2,051	1,742	4,573	4,172
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	2,298		2,298
Weighted-average Recognition Period (in years)	5 months 23 days
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	25,740	19,777	45,089	36,981
Sales, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	$ 15,610	$ 11,602	$ 27,536	$ 22,086