Stock-based Compensation Expense (Details) (USD $) In Thousands, unless otherwise specified	3 Months Ended
	Mar. 31, 2013	Mar. 31, 2012
Stock-based compensation expense:
Less stock-based compensation expense capitalized to inventories	$ (299)	$ (250)
Total stock-based compensation expense included in costs and expenses	31,275	27,688
Stock options
Stock-based compensation expense:
Stock-based compensation expense by type of award	19,674	18,222
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	187,456
Weighted-average Recognition Period (in years)	2 years 10 months 24 days
Restricted stock and restricted stock units
Stock-based compensation expense:
Stock-based compensation expense by type of award	9,378	7,286
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	86,795
Weighted-average Recognition Period (in years)	2 years 6 months 29 days
ESPP share issuances
Stock-based compensation expense:
Stock-based compensation expense by type of award	2,522	2,430
Type of award:
Unrecognized Expense, Net of Estimated Forfeitures	3,091
Weighted-average Recognition Period (in years)	5 months 27 days
Research and development expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	19,349	17,204
Sales, general and administrative expenses
Stock-based compensation expense:
Total stock-based compensation expense included in costs and expenses	$ 11,926	$ 10,484