CONFIRMING STATEMENT
of Signature Authority



	This Statement confirms that the
undersigned has authorized and designated
Kenneth S. Boger, Valerie L. Andrews,
Michelle O. Rosen and Anne L. Bruno, and
each of them acting alone, to execute and
file on behalf of the undersigned any and
all Forms 3, 4 and 5 (including any
amendments thereto) that the undersigned
may be required to file with the United
States Securities and Exchange Commission
as a result of the undersigned's ownership
of or transactions in securities of Vertex
Pharmaceuticals Incorporated. The
authority of Kenneth S. Boger, Valerie L.
Andrews, Michelle O. Rosen and Anne L.
Bruno under this Statement shall continue
until the undersigned is no longer
required to file Forms 3, 4 or 5 with
regard to the undersigned's ownership of
or transactions in securities of Vertex
Pharmaceuticals Incorporated, unless
earlier revoked in writing. The
undersigned acknowledges that Kenneth S.
Boger, Valerie L. Andrews, Michelle O.
Rosen and Anne L. Bruno are not assuming,
nor is Vertex Pharmaceuticals Incorporated
assuming, any of the undersigned's
responsibilities to comply with Section 16
of the Securities Act of 1934.

This Statement supersedes and replaces any
earlier dated Statement that the
undersigned has executed.


												By: /s/ Peter Mueller

												Date: July 15, 2003