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Condensed Consolidated Statements of Cash Flows (Unaudited) (USD $)
In Thousands
9 Months Ended
Sep. 30, 2011
Sep. 30, 2010
Cash flows from operating activities:  
Net income$ 966,476$ 626,821
Adjustments to reconcile net income to net cash flows from operating activities:  
Depreciation and amortization of property, plant and equipment and intangible assets270,212260,089
Acquired in-process research and development 271,376
Share-based compensation86,625134,594
Fair value adjustment of contingent consideration5,900 
Excess tax benefit from share-based compensation(43,545)(6,284)
Deferred income taxes115,698(61,244)
Write-down of inventory to net realizable value16,8639,918
Impairment of marketable securities, investments and other assets5,29219,319
Non-cash interest (income) expense, foreign exchange remeasurement loss (gain), net and other15,3771,124
Realized gain on sale of marketable securities and strategic investments(15,380)(16,113)
(Gain) loss on disposal of property, plant and equipment, net 1,748
Changes in operating assets and liabilities, net:  
Accounts receivable(17,334)(72,719)
Due from unconsolidated joint business(9,123)(27,829)
Inventory(35,767)16,311
Other assets(31,115)(22,435)
Accrued expenses and other current liabilities(56,737)17,377
Other liabilities and taxes payable(19,675)41,564
Net cash flows provided by operating activities1,253,7671,193,617
Cash flows from investing activities:  
Proceeds from sales and maturities of marketable securities1,476,0522,490,363
Purchases of marketable securities(2,590,971)(1,371,769)
Acquisitions (39,976)
Acquisition of a variable interest entity, net (84,952)
Purchases of property, plant and equipment(137,578)(124,220)
Proceeds from the sale of property, plant and equipment2,155 
Purchases of intangible assets(44,153) 
Purchases of other investments(6,514)(5,499)
Proceeds from the sale of strategic investments40,247 
Net cash flows (used in) provided by investing activities(1,260,762)863,947
Cash flows from financing activities:  
Purchase of treasury stock(386,575)(2,077,579)
Proceeds from issuance of stock for share-based compensation arrangements299,46680,447
Excess tax benefit from share-based compensation43,5456,284
Change in cash overdraft(3,032)2,586
Acquisition of noncontrolling interest(91,724) 
Net distributions to noncontrolling interests(24,112)(6,401)
Repayments of borrowings(11,460)(16,182)
Repayments on financing arrangement for the sale of the San Diego facility(3,161) 
Net cash flows used in financing activities(177,053)(2,010,845)
Net (decrease) increase in cash and cash equivalents(184,048)46,719
Effect of exchange rate changes on cash and cash equivalents(410)(1,851)
Cash and cash equivalents, beginning of the period759,598581,889
Cash and cash equivalents, end of the period$ 575,140$ 626,757