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Other Consolidated Financial Statement Detail (Tables)
 12 Months Ended
Dec. 31, 2025
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Supplemental cash flow information
The following table presents income taxes paid (net of refunds received) for the year ended December 31, 2025.
(In millions)For the Year Ended December 31, 2025
Federal$721.0 
State48.4
Foreign94.6
Total$864.0 
Supplemental disclosure of cash flow information is summarized as follows:
 For the Years Ended December 31,
(In millions)202520242023
Cash paid during the year for:
Interest$264.1 $245.4 $252.2 
Income taxes864.0 355.1 740.7 
Other income (expense), net
Components of other (income) expense, net, are summarized as follows:
 For the Years Ended December 31,
(In millions)202520242023
Interest income$(125.0)$(67.6)$(276.5)
Interest expense267.5 250.3 246.9 
(Gains) losses on investments, net19.7 100.4 291.2 
Litigation related expense139.5 26.3 3.9 
Foreign exchange (gains) losses, net28.6 30.9 50.4 
Other, net(24.7)3.3 (0.4)
Total other (income) expense, net$305.6 $343.6 $315.5 
Gain (loss) on investments
The following table summarizes our (gains) losses on investments, net that relate to our equity securities held during the following periods:
 For the Years Ended December 31,
(In millions)202520242023
Net (gains) losses recognized on equity securities$19.7 $100.4 $275.2 
Less: Net (gains) losses realized on equity securities1.5 (2.0)5.2 
Net unrealized (gains) losses recognized on equity securities$18.2 $102.4 $270.0 
Accrued expense and other
Accrued expense and other consists of the following:
 As of December 31,
(In millions)20252024
Revenue-related reserves for discounts and allowances$1,000.4 $937.5 
Employee compensation and benefits375.8 375.8 
Collaboration expense280.0 309.0 
Royalties and licensing fees302.4 190.2 
Current portion of contingent consideration obligations— 291.2 
Other844.0 704.0 
Total accrued expense and other$2,802.6 $2,807.7